Normalisation of CD4 count in an individual with HIV

Pritsana Khamchaew, Edwin ten Winkel, bbPharma

A 35 year old Chino-Thai male with previously diagnosed HIV and onset of AIDS was included in a clinical trial investigating effect of BBP153 on CD4 count in patients with HIV. Baseline value upon entry of the trial for this patient was 221 CD4 cells/mm3. He received 1 gram of BBP153 daily. CD4 count was repeated after 8 weeks and 912 CD4 cells/mm3 were found while symptoms were cleared. Normal CD4 values in Caucasians are reported to be 500-1500 cells/mm³¹, whereas for Ethnical Chinese, sometimes lower normal values are reported (727 ± 255 cells/μl). These results are promising but a full analysis of the trial needs to be made.

12 December 2008. The man remains to be symptom free and has normalized CD4 count

1. Normal Values for CD4 and CD8 Lymphocyte Subsets in Healthy Chinese Adults from Shanghai
Weiming Jiang, Laiyi Kang, Hong-Zhou Lu, Xiaozhang Pan, Qingneng Lin, Qichao Pan, Yile Xue, Xinhua Weng, and Yi-Wei Tang

Effects of Coccinia indica and tolbutamide on human bloodsuger values

Pritsana Khamchaew, Edwin ten Winkel, bbPharma

Abstract. Coccinia indica (Climbing ivy gourd) is a herb used in traditional and Ayurvedic medicine in India where it is often combined with Abroma augusta.

100 patients with confirmed type II Diabetes mellitus were rondomized over two groups. One group received 2dd 200mg/kg of Coccinia indica (in watery extract, freeze dried and encapsulated), wheras the other group recieved Tolbutamide 2dd 200mg/kg. Treatment results were determined after 45 days.

Both Coccinia Indica and Tolbutamide caused a statistical and clinically significant lowering of bloodsuger values in comparison to base values. There were no statistically significant differences between patients treated with Coccinia Indica and patients treated with tolbutamide.