Lam Hoi-ka, E. ten Winkel, bbPharma
Certain drugs such as mianserin have been reported to extend the lifespan in worms by 30%. We have tested BBP750 a serotonin modulator with octopamine inhibiting effects.
Caenorhabditis elegans on BBP750 enhanced diet showed a 25% boost in lifespan compared to C. elegans on a regular diet (bacterial lawn grown on an agar plate, with and without BBP750 enrichment). No Dauer stadia were seen
Interestingly, effects from other studies on BBP750 show that rats have slightly decreased food-intake compared to rats on a regular diet.
Monday, 28 April 2008
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